EVOLUTION – Genetic Novelty/Genomic Variations
by RNA Networks and Viruses
For more than half a century it has been accepted that new genetic information is mostly derived from random‚ error-based’ events. Now it is recognized that errors cannot explain genetic novelty and complexity.
Empirical evidence establishes the crucial role of non-random genetic content editors such as viruses and RNA-networks to create genetic novelty, complex regulatory control, inheritance vectors, genetic identity, immunity, new sequence space, evolution of complex organisms and evolutionary transitions.
Genetic identities of RNA stem loop groups (RNA-networks) such as e.g., group I introns, group II introns, viroids, RNA viruses, retrotransposons, LTRs, non-LTRs and subviral networks such as SINEs, LINEs, Alus invade and even persist in host genomes. Also mixed consortia of RNA- and DNA-virus derived parts that integrate in host genomes have been found. Highly dynamic RNA-Protein networks such as Ribosome, Editosome and Spliceosome generate a large variety of results out of DNA content.
Genome invading agents such a viruses and RNA-networks represent a very large and dynamic source of genetic novelty. They can co-operate, build communities, generate nucleotide sequences de novo and insert/delete them into host genetic content. Viruses and RNA-networks often remain as mobile genetic elements or similar ‚defectives’ and determine host genetic identities throughout all kingdoms including the virosphere. But inclusion of a transmissive viral biology differs fundamentally from conventional thinking in that it represents a vertical domain of life providing vast amounts of linked information not derrived from direct ancestors.
This new empirically based perspective on the evolution of genetic novelty will have more explanatory power in the future than the „error-replication“ narrative of the last century.
I M P R E S S U M :
Inhaber der Domäne “rna-networks.at” und für den Inhalt verantwortlich:
Dr. Mag. Günther Witzany
A 5111 Bürmoos
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